Nef enhances HIV-1 replication and infectivity independently of SERINC5 in CEM T cells

A primary function of HIV-1 Nef is the enhancement of viral infectivity and replication. Whether counteraction of the antiretroviral proteins SERINC3 and SERINC5 is the cause of this positive influence on viral growth-rate and infectivity remains unclear. Here, we utilized CRISPR/Cas9 to knockout SE...

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Detalles Bibliográficos
Autores principales: Ramirez, Peter W., Vollbrecht, Thomas, Acosta, Francisco M., Suarez, Marissa, Angerstein, Aaron O., Wallace, Jared, O’ Connell, Ryan M., Guatelli, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484624/
https://www.ncbi.nlm.nih.gov/pubmed/36577173
http://dx.doi.org/10.1016/j.virol.2022.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484624/
https://www.ncbi.nlm.nih.gov/pubmed/36577173
http://dx.doi.org/10.1016/j.virol.2022.12.008

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