Evaluating genomic signatures of aging in brain tissue as it relates to Alzheimer’s disease

Telomere length (TL) attrition, epigenetic age acceleration, and mitochondrial DNA copy number (mtDNAcn) decline are established hallmarks of aging. Each has been individually associated with Alzheimer’s dementia, cognitive function, and pathologic Alzheimer’s disease (AD). Epigenetic age and mtDNAc...

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Detalles Bibliográficos
Autores principales: Lynch, Megan T., Taub, Margaret A., Farfel, Jose M., Yang, Jingyun, Abadir, Peter, De Jager, Philip L., Grodstein, Francine, Bennett, David A., Mathias, Rasika A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484923/
https://www.ncbi.nlm.nih.gov/pubmed/37679407
http://dx.doi.org/10.1038/s41598-023-41400-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484923/
https://www.ncbi.nlm.nih.gov/pubmed/37679407
http://dx.doi.org/10.1038/s41598-023-41400-1

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