Exploring a new mechanism between lactate and VSMC calcification: PARP1/POLG/UCP2 signaling pathway and imbalance of mitochondrial homeostasis

Lactate leads to the imbalance of mitochondria homeostasis, which then promotes vascular calcification. PARP1 can upregulate osteogenic genes and accelerate vascular calcification. However, the relationship among lactate, PARP1, and mitochondrial homeostasis is unclear. The present study aimed to ex...

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Detalles Bibliográficos
Autores principales: Zhu, Yi, Zhang, Jia-li, Yan, Xue-jiao, Ji, Yuan, Wang, Fang-fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484939/
https://www.ncbi.nlm.nih.gov/pubmed/37679327
http://dx.doi.org/10.1038/s41419-023-06113-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484939/
https://www.ncbi.nlm.nih.gov/pubmed/37679327
http://dx.doi.org/10.1038/s41419-023-06113-3

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