Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif

Antibiotics target key biological processes that include protein synthesis. Bacteria respond by developing resistance, which increases rapidly due to antibiotics overuse. Mupirocin, a clinically used natural antibiotic, inhibits isoleucyl-tRNA synthetase (IleRS), an enzyme that links isoleucine to i...

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Detalles Bibliográficos
Autores principales: Brkic, A., Leibundgut, M., Jablonska, J., Zanki, V., Car, Z., Petrovic Perokovic, V., Marsavelski, A., Ban, N., Gruic-Sovulj, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485003/
https://www.ncbi.nlm.nih.gov/pubmed/37679387
http://dx.doi.org/10.1038/s41467-023-41244-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485003/
https://www.ncbi.nlm.nih.gov/pubmed/37679387
http://dx.doi.org/10.1038/s41467-023-41244-3

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