TRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs

Deletion of TRAF2 or TRAF3 in B cells prolongs their survival. However, it remains unknown whether deletion of such factors affects B cells’ ability to tolerate DNA damage, which can be induced by chemotherapeutics and cause apoptosis. Genetic alterations of TRAF2 or TRAF3 are observed in subsets of...

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Detalles Bibliográficos
Autores principales: Vashisht, Monika, Ge, Huaibin, John, Jessy, McKelvey, Harlie A., Chen, Jingxin, Chen, Zhangguo, Wang, Jing H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485046/
https://www.ncbi.nlm.nih.gov/pubmed/37679334
http://dx.doi.org/10.1038/s41419-023-06122-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485046/
https://www.ncbi.nlm.nih.gov/pubmed/37679334
http://dx.doi.org/10.1038/s41419-023-06122-2

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