Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis

INTRODUCTION: Defective lymphatic drainage and translocation of B-cells in inflamed (Bin) joint-draining lymph node sinuses are pathogenic phenomena in patients with severe rheumatoid arthritis (RA). However, the molecular mechanisms underlying this lymphatic dysfunction remain poorly understood. He...

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Detalles Bibliográficos
Autores principales: Kenney, H. Mark, Rangel-Moreno, Javier, Peng, Yue, Chen, Kiana L., Bruno, Jennifer, Embong, Abdul, Pritchett, Elizabeth, Fox, Jeffrey I., Becerril-Villanueva, Enrique, Gamboa-Domínguez, Armando, Quataert, Sally, Muthukrishnan, Gowrishankar, Wood, Ronald W., Korman, Benjamin D., Anolik, Jennifer H., Xing, Lianping, Ritchlin, Christopher T., Schwarz, Edward M., Wu, Chia-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485835/
https://www.ncbi.nlm.nih.gov/pubmed/37691918
http://dx.doi.org/10.3389/fimmu.2023.1237498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485835/
https://www.ncbi.nlm.nih.gov/pubmed/37691918
http://dx.doi.org/10.3389/fimmu.2023.1237498

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