Transcription-wide impact by RESCUE-induced off-target single-nucleotide variants in mammalian cells

RNA base editing is a promising tool in precise molecular therapy. Currently, there are two widely used RNA base editors, REPAIR and RESCUE. REPAIR only facilitates A-to-I conversions, while RESCUE performs both A-to-I and C-to-U conversions. Thus, RESCUE can generate twice the number of mutations c...

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Detalles Bibliográficos
Autores principales: Li, Guo, Zhu, Xiaoning, Wang, Yihan, Ma, Hongru, Wang, Yuzhe, Wu, Hanyu, Li, Xiangyang, Wang, Yiling, Gao, Jianen, Chen, Xuexin, Huang, Xingxu, Yao, Yuan, Hu, Xiaoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485882/
https://www.ncbi.nlm.nih.gov/pubmed/36822625
http://dx.doi.org/10.1093/jmcb/mjad011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485882/
https://www.ncbi.nlm.nih.gov/pubmed/36822625
http://dx.doi.org/10.1093/jmcb/mjad011

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