Cargando…

Transcription-wide impact by RESCUE-induced off-target single-nucleotide variants in mammalian cells

RNA base editing is a promising tool in precise molecular therapy. Currently, there are two widely used RNA base editors, REPAIR and RESCUE. REPAIR only facilitates A-to-I conversions, while RESCUE performs both A-to-I and C-to-U conversions. Thus, RESCUE can generate twice the number of mutations c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Guo, Zhu, Xiaoning, Wang, Yihan, Ma, Hongru, Wang, Yuzhe, Wu, Hanyu, Li, Xiangyang, Wang, Yiling, Gao, Jianen, Chen, Xuexin, Huang, Xingxu, Yao, Yuan, Hu, Xiaoxiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485882/ https://www.ncbi.nlm.nih.gov/pubmed/36822625 http://dx.doi.org/10.1093/jmcb/mjad011

Ejemplares similares

ecRESCUE: a novel ecDHFR-regulated RESCUE system with reduced RNA off-targeting activity
por: Wang, Yihan, et al.
Publicado: (2021)

Developing PspCas13b-based enhanced RESCUE system, eRESCUE, with efficient RNA base editing
por: Li, Guo, et al.
Publicado: (2021)

Serum metabolic profile and metabolome genome-wide association study in chicken
por: Tian, Jing, et al.
Publicado: (2023)

Genomic prediction based on selective linkage disequilibrium pruning of low-coverage whole-genome sequence variants in a pure Duroc population
por: Zhu, Di, et al.
Publicado: (2023)

Off-Targeting of Base Editors: BE3 but not ABE induces substantial off-target single nucleotide variants
por: Xin, Huhu, et al.
Publicado: (2019)

Genome‑wide association study and genomic prediction for growth traits in yellow-plumage chicken using genotyping-by-sequencing
por: Yang, Ruifei, et al.
Publicado: (2021)

Replication fork rescue in mammalian mitochondria
por: Torregrosa-Muñumer, Rubén, et al.
Publicado: (2019)

Improving the Accuracy of Single-Nucleotide Variant Diagnosis Using On–Off Discriminating Primers
por: Shin, Juny, et al.
Publicado: (2023)

Rescue of high-specificity Cas9 variants using sgRNAs with matched 5’ nucleotides
por: Kim, Sojung, et al.
Publicado: (2017)

CABE-RY: A PAM-flexible dual-mutation base editor for reliable modeling of multi-nucleotide variants
por: Tao, Wanyu, et al.
Publicado: (2021)

Genome-wide piggyBac transposon mediated screening reveals genes related to reprogramming
por: Zhang, Xi, et al.
Publicado: (2016)

A novel base editor SpRY-ABE8e(F148A) mediates efficient A-to-G base editing with a reduced off-target effect
por: Li, Guo, et al.
Publicado: (2022)

Regulation of mammalian nucleotide metabolism and biosynthesis
por: Lane, Andrew N, et al.
Publicado: (2015)

Genome-wide identification and characterization of GRAS transcription factors in tomato (Solanum lycopersicum)
por: Niu, Yiling, et al.
Publicado: (2017)

Watch Out for a Second SNP: Focus on Multi-Nucleotide Variants in Coding Regions and Rescued Stop-Gained
por: Degalez, Fabien, et al.
Publicado: (2021)

Genome-wide analysis of structural variants reveals genetic differences in Chinese pigs
por: Yang, Ruifei, et al.
Publicado: (2017)

Using DIVAN to assess disease/trait-associated single nucleotide variants in genome-wide scale
por: Chen, Li, et al.
Publicado: (2017)

Structural basis for mammalian nucleotide sugar transport
por: Ahuja, Shivani, et al.
Publicado: (2019)

Anesthesiologist to surgeons’ rescue: An off label use of choledochoscope
por: Aggarwal, Shiba, et al.
Publicado: (2012)

Rescue the Failed Half-ZFN by a Sensitive Mammalian Cell-Based Luciferase Reporter System
por: Zhang, Weifeng, et al.
Publicado: (2012)

Genome-wide segregation of single nucleotide and structural variants into single cancer cells
por: Easton, John, et al.
Publicado: (2017)

Prediction of genome-wide effects of single nucleotide variants on transcription factor binding
por: Carrasco Pro, Sebastian, et al.
Publicado: (2020)

Engineering of near-PAMless adenine base editor with enhanced editing activity and reduced off-target
por: Cao, Xiaofang, et al.
Publicado: (2022)

Genome-Wide Association Study of Nucleotide Variants Associated with Resistance to Nine Antimicrobials in Mycoplasma bovis
por: Waldner, Matthew, et al.
Publicado: (2022)

A massively parallel approach for assessing CRISPR off-targets in vitro
por: Huang, Shisheng, et al.
Publicado: (2023)

The miR-133b/brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1) axis represses proliferation, invasion, and migration in cervical cancer cells
por: Jiang, Lingling, et al.
Publicado: (2022)

BDNF-TrkB/proBDNF-p75(NTR) pathway regulation by lipid emulsion rescues bupivacaine-induced central neurotoxicity in rats
por: Jia, Danting, et al.
Publicado: (2023)

Nucleotide metabolic mismatches in mammalian hearts: implications for transplantation
por: Khalpey, Z, et al.
Publicado: (2013)

Genome-wide association study reveals the genetic determinism of growth traits in a Gushi-Anka F(2) chicken population
por: Zhang, Yanhua, et al.
Publicado: (2020)

Optimized double-digest genotyping by sequencing (ddGBS) method with high-density SNP markers and high genotyping accuracy for chickens
por: Wang, Yuzhe, et al.
Publicado: (2017)

Rescue of Infectious Sindbis Virus by Yeast Spheroplast-Mammalian Cell Fusion
por: Ding, Lin, et al.
Publicado: (2021)

Genome-wide identification and expression analysis of the cyclic nucleotide-gated ion channel (CNGC) gene family in Saccharum spontaneum
por: Zhang, Nannan, et al.
Publicado: (2023)

High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets
por: Kleinstiver, Benjamin P., et al.
Publicado: (2016)

Analysis of Single Nucleotide Variants in CRISPR-Cas9 Edited Zebrafish Exomes Shows No Evidence of Off-Target Inflation
por: Mooney, Marie R., et al.
Publicado: (2019)

Drugs to the Rescue: Comparison of On-Demand Therapies for OFF Symptoms in Parkinson’s Disease
por: Martinez-Nunez, Alfonso E., et al.
Publicado: (2023)

Cyclic nucleotide regulation of the contractile proteins in mammalian cardiac muscle
Publicado: (1980)

New synthetic substrates of mammalian nucleotide excision repair system
por: Evdokimov, Alexey, et al.
Publicado: (2013)

Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs
por: Sharma, Sunny, et al.
Publicado: (2020)

Publisher Correction: Prediction of genome-wide effects of single nucleotide variants on transcription factor binding
por: Carrasco Pro, Sebastian, et al.
Publicado: (2021)

Nucleotide excision repair removes thymidine analog 5-ethynyl-2′-deoxyuridine from the mammalian genome
por: Wang, Li, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lnsr21k3eh6tau375ndhq55pue