Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabetics

BACKGROUND: First-degree relatives of type 2 diabetics (FDR) exhibit a high risk of developing type 2 diabetes (T2D) and feature subcutaneous adipocyte hypertrophy, independent of obesity. In FDR, adipose cell abnormalities contribute to early insulin-resistance and are determined by adipocyte precu...

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Detalles Bibliográficos
Autores principales: Longo, Michele, Zatterale, Federica, Spinelli, Rosa, Naderi, Jamal, Parrillo, Luca, Florese, Pasqualina, Nigro, Cecilia, Leone, Alessia, Moccia, Augusta, Desiderio, Antonella, Raciti, Gregory A., Miele, Claudia, Smith, Ulf, Beguinot, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486065/
https://www.ncbi.nlm.nih.gov/pubmed/37679776
http://dx.doi.org/10.1186/s13148-023-01556-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486065/
https://www.ncbi.nlm.nih.gov/pubmed/37679776
http://dx.doi.org/10.1186/s13148-023-01556-z

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