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Amorphous Solid Forms of Ranolazine and Tryptophan and Their Relaxation to Metastable Polymorphs
[Image: see text] Different methods were explored for the amorphization of ranolazine, a sparingly soluble anti-anginal drug, such as mechanochemistry, quench-cooling, and solvent evaporation from solutions. Amorphous phases, with T(g) values lower than room temperature, were obtained by cryo-millin...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486308/ https://www.ncbi.nlm.nih.gov/pubmed/37692331 http://dx.doi.org/10.1021/acs.cgd.3c00565 |