Co-Expression of an IL-15 Superagonist Facilitates Self-Enrichment of GD(2)-Targeted CAR-NK Cells and Mediates Potent Cell Killing in the Absence of IL-2

SIMPLE SUMMARY: The disialoganglioside GD(2) is produced at high levels by neuroblastomas and other tumors of neuroectodermal origin, where its expression correlates with increased tumor progression and poor prognosis. Although established therapies with GD(2)-specific antibodies can be efficacious,...

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Detalles Bibliográficos
Autores principales: Bodden, Malena, Häcker, Aline, Röder, Jasmin, Kiefer, Anne, Zhang, Congcong, Bhatti, Anita, Pfeifer Serrahima, Jordi, Ullrich, Evelyn, Kühnel, Ines, Wels, Winfried S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486391/
https://www.ncbi.nlm.nih.gov/pubmed/37686586
http://dx.doi.org/10.3390/cancers15174310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486391/
https://www.ncbi.nlm.nih.gov/pubmed/37686586
http://dx.doi.org/10.3390/cancers15174310

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