Antagonizing MDM2 Overexpression Induced by MDM4 Inhibitor CEP-1347 Effectively Reactivates Wild-Type p53 in Malignant Brain Tumor Cells

SIMPLE SUMMARY: In human cancer, the major tumor suppressor p53 is often functionally inactivated through the deregulation of its negative regulators MDM2 and MDM4. The inhibitors of MDM4 have recently been attracting increasing attention as a promising approach to the reactivation of wild-type p53...

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Detalles Bibliográficos
Autores principales: Mitobe, Yuta, Suzuki, Shuhei, Nakagawa-Saito, Yurika, Togashi, Keita, Sugai, Asuka, Sonoda, Yukihiko, Kitanaka, Chifumi, Okada, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486490/
https://www.ncbi.nlm.nih.gov/pubmed/37686602
http://dx.doi.org/10.3390/cancers15174326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486490/
https://www.ncbi.nlm.nih.gov/pubmed/37686602
http://dx.doi.org/10.3390/cancers15174326

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