Role of Leptin and Adiponectin in Carcinogenesis

SIMPLE SUMMARY: The involvement of leptin and adiponectin with receptors in the formation of many types of cancer as well as their impact on the clinical course of cancer patients are well established; however, the mechanisms of action of these adipokines are difficult to understand and thus need to...

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Autores principales: Bocian-Jastrzębska, Agnes, Malczewska-Herman, Anna, Kos-Kudła, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486522/
https://www.ncbi.nlm.nih.gov/pubmed/37686525
http://dx.doi.org/10.3390/cancers15174250
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author Bocian-Jastrzębska, Agnes
Malczewska-Herman, Anna
Kos-Kudła, Beata
author_facet Bocian-Jastrzębska, Agnes
Malczewska-Herman, Anna
Kos-Kudła, Beata
author_sort Bocian-Jastrzębska, Agnes
collection PubMed
description SIMPLE SUMMARY: The involvement of leptin and adiponectin with receptors in the formation of many types of cancer as well as their impact on the clinical course of cancer patients are well established; however, the mechanisms of action of these adipokines are difficult to understand and thus need to be clarified. This review comprehensively presents in a systematized manner the implication of leptin and adiponectin in different stages of cancer development, focusing on interactions with the tumor microenvironment and its components in addition to their impact on the epithelial–mesenchymal transition and angiogenesis. A solid insight into these mechanisms is essential for the future potential use of these adipokines in cancer diagnostics and therapeutics. ABSTRACT: Hormones produced by adipocytes, leptin and adiponectin, are associated with the process of carcinogenesis. Both of these adipokines have well-proven oncologic potential and can affect many aspects of tumorigenesis, from initiation and primary tumor growth to metastatic progression. Involvement in the formation of cancer includes interactions with the tumor microenvironment and its components, such as tumor-associated macrophages, cancer-associated fibroblasts, extracellular matrix and matrix metalloproteinases. Furthermore, these adipokines participate in the epithelial–mesenchymal transition and connect to angiogenesis, which is critical for cancer invasiveness and cancer cell migration. In addition, an enormous amount of evidence has demonstrated that altered concentrations of these adipocyte-derived hormones and the expression of their receptors in tumors are associated with poor prognosis in various types of cancer. Therefore, leptin and adiponectin dysfunction play a prominent role in cancer and impact tumor invasion and metastasis in different ways. This review clearly and comprehensively summarizes the recent findings and presents the role of leptin and adiponectin in cancer initiation, promotion and progression, focusing on associations with the tumor microenvironment and its components as well as roles in the epithelial–mesenchymal transition and angiogenesis.
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spelling pubmed-104865222023-09-09 Role of Leptin and Adiponectin in Carcinogenesis Bocian-Jastrzębska, Agnes Malczewska-Herman, Anna Kos-Kudła, Beata Cancers (Basel) Review SIMPLE SUMMARY: The involvement of leptin and adiponectin with receptors in the formation of many types of cancer as well as their impact on the clinical course of cancer patients are well established; however, the mechanisms of action of these adipokines are difficult to understand and thus need to be clarified. This review comprehensively presents in a systematized manner the implication of leptin and adiponectin in different stages of cancer development, focusing on interactions with the tumor microenvironment and its components in addition to their impact on the epithelial–mesenchymal transition and angiogenesis. A solid insight into these mechanisms is essential for the future potential use of these adipokines in cancer diagnostics and therapeutics. ABSTRACT: Hormones produced by adipocytes, leptin and adiponectin, are associated with the process of carcinogenesis. Both of these adipokines have well-proven oncologic potential and can affect many aspects of tumorigenesis, from initiation and primary tumor growth to metastatic progression. Involvement in the formation of cancer includes interactions with the tumor microenvironment and its components, such as tumor-associated macrophages, cancer-associated fibroblasts, extracellular matrix and matrix metalloproteinases. Furthermore, these adipokines participate in the epithelial–mesenchymal transition and connect to angiogenesis, which is critical for cancer invasiveness and cancer cell migration. In addition, an enormous amount of evidence has demonstrated that altered concentrations of these adipocyte-derived hormones and the expression of their receptors in tumors are associated with poor prognosis in various types of cancer. Therefore, leptin and adiponectin dysfunction play a prominent role in cancer and impact tumor invasion and metastasis in different ways. This review clearly and comprehensively summarizes the recent findings and presents the role of leptin and adiponectin in cancer initiation, promotion and progression, focusing on associations with the tumor microenvironment and its components as well as roles in the epithelial–mesenchymal transition and angiogenesis. MDPI 2023-08-24 /pmc/articles/PMC10486522/ /pubmed/37686525 http://dx.doi.org/10.3390/cancers15174250 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bocian-Jastrzębska, Agnes
Malczewska-Herman, Anna
Kos-Kudła, Beata
Role of Leptin and Adiponectin in Carcinogenesis
title Role of Leptin and Adiponectin in Carcinogenesis
title_full Role of Leptin and Adiponectin in Carcinogenesis
title_fullStr Role of Leptin and Adiponectin in Carcinogenesis
title_full_unstemmed Role of Leptin and Adiponectin in Carcinogenesis
title_short Role of Leptin and Adiponectin in Carcinogenesis
title_sort role of leptin and adiponectin in carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486522/
https://www.ncbi.nlm.nih.gov/pubmed/37686525
http://dx.doi.org/10.3390/cancers15174250
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