Interpreting the Mechanism of Synergism for Drug Combinations Using Attention-Based Hierarchical Graph Pooling

SIMPLE SUMMARY: This paper introduces a novel graph neural network (a hierarchical graph pooling model), SANEpool, to effectively detect core sub-networks of significant genes for predicting the synergy score of drug/drug combinations in cancer. SANEpool successfully addresses the limitations of the...

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Detalles Bibliográficos
Autores principales: Dong, Zehao, Zhang, Heming, Chen, Yixin, Payne, Philip R. O., Li, Fuhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486573/
https://www.ncbi.nlm.nih.gov/pubmed/37686486
http://dx.doi.org/10.3390/cancers15174210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486573/
https://www.ncbi.nlm.nih.gov/pubmed/37686486
http://dx.doi.org/10.3390/cancers15174210

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