Discovery of VIP236, an αvβ3-Targeted Small-Molecule–Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors

SIMPLE SUMMARY: The goal of this work was to improve the tumor selectivity of chemotherapy to reduce side effects and improve efficacy. We designed a drug called VIP236 that delivers chemotherapy directly to tumors due to a specialized “homing feature” that binds to αvβ3 integrins. Solid tumors expr...

Descripción completa

Detalles Bibliográficos
Autores principales: Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Heroult, Melanie, Zubov, Dmitry, Gericke, Kersten Matthias, Wong, Harvey, Frigault, Melanie M., Johnson, Amy J., Izumi, Raquel, Hamdy, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486604/
https://www.ncbi.nlm.nih.gov/pubmed/37686656
http://dx.doi.org/10.3390/cancers15174381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486604/
https://www.ncbi.nlm.nih.gov/pubmed/37686656
http://dx.doi.org/10.3390/cancers15174381

Ejemplares similares