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Discovery of VIP236, an αvβ3-Targeted Small-Molecule–Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors
SIMPLE SUMMARY: The goal of this work was to improve the tumor selectivity of chemotherapy to reduce side effects and improve efficacy. We designed a drug called VIP236 that delivers chemotherapy directly to tumors due to a specialized “homing feature” that binds to αvβ3 integrins. Solid tumors expr...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486604/ https://www.ncbi.nlm.nih.gov/pubmed/37686656 http://dx.doi.org/10.3390/cancers15174381 |