The Impact of ETV6-NTRK3 Oncogenic Gene Fusions on Molecular and Signaling Pathway Alterations

SIMPLE SUMMARY: Gene fusions produce chimeric fusion proteins with unpredictable properties, many of which function as oncogenic drivers. ETV6-NTRK3 produces a constitutively active fusion kinase, which is not membrane bound like the endogenous NTRK3 kinase. Several studies have investigated the int...

Descripción completa

Detalles Bibliográficos
Autores principales: Kinnunen, Matias, Liu, Xiaonan, Niemelä, Elina, Öhman, Tiina, Gawriyski, Lisa, Salokas, Kari, Keskitalo, Salla, Varjosalo, Markku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486691/
https://www.ncbi.nlm.nih.gov/pubmed/37686522
http://dx.doi.org/10.3390/cancers15174246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486691/
https://www.ncbi.nlm.nih.gov/pubmed/37686522
http://dx.doi.org/10.3390/cancers15174246

Ejemplares similares