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The Impact of ETV6-NTRK3 Oncogenic Gene Fusions on Molecular and Signaling Pathway Alterations
SIMPLE SUMMARY: Gene fusions produce chimeric fusion proteins with unpredictable properties, many of which function as oncogenic drivers. ETV6-NTRK3 produces a constitutively active fusion kinase, which is not membrane bound like the endogenous NTRK3 kinase. Several studies have investigated the int...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486691/ https://www.ncbi.nlm.nih.gov/pubmed/37686522 http://dx.doi.org/10.3390/cancers15174246 |