Stable Chinese Hamster Ovary Suspension Cell Lines Harboring Recombinant Human Cytochrome P450 Oxidoreductase and Human Cytochrome P450 Monooxygenases as Platform for In Vitro Biotransformation Studies

In the liver, phase-1 biotransformation of drugs and other xenobiotics is largely facilitated by enzyme complexes consisting of cytochrome P450 oxidoreductase (CPR) and cytochrome P450 monooxygenases (CYPs). Generated from human liver-derived cell lines, recombinant in vitro cell systems with overex...

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Detalles Bibliográficos
Autores principales: Schulz, Christian, Herzog, Natalie, Kubick, Stefan, Jung, Friedrich, Küpper, Jan-Heiner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486802/
https://www.ncbi.nlm.nih.gov/pubmed/37681872
http://dx.doi.org/10.3390/cells12172140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486802/
https://www.ncbi.nlm.nih.gov/pubmed/37681872
http://dx.doi.org/10.3390/cells12172140

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