Slow Interstitial Fluid Flow Activates TGF-β Signaling and Drives Fibrotic Responses in Human Tenon Fibroblasts

Background: Fibrosis limits the success of filtering glaucoma surgery. We employed 2D and 3D in vitro models to assess the effects of fluid flow on human tenon fibroblasts (HTF). Methods: HTF were exposed to continuous or pulsatile fluid flow for 48 or 72 h, at rates expected at the transscleral out...

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Detalles Bibliográficos
Autores principales: Wiedenmann, Cornelius Jakob, Gottwald, Charlotte, Zeqiri, Kosovare, Frömmichen, Janne, Bungert, Emma, Gläser, Moritz, Ströble, Jeanne, Lohmüller, Robert, Reinhard, Thomas, Lübke, Jan, Schlunck, Günther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486805/
https://www.ncbi.nlm.nih.gov/pubmed/37681937
http://dx.doi.org/10.3390/cells12172205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486805/
https://www.ncbi.nlm.nih.gov/pubmed/37681937
http://dx.doi.org/10.3390/cells12172205

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