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Anti-Inflammatory and Immune Properties of Polyunsaturated Fatty Acids (PUFAs) and Their Impact on Colorectal Cancer (CRC) Prevention and Treatment

SIMPLE SUMMARY: In our review, we investigate polyunsaturated fatty acids, or PUFAs for short, and their potential role in preventing and treating colorectal cancer (CRC). We are inspired to do this research because CRC is becoming more common, and we are always looking for new ways to tackle it. We...

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Autores principales: Tojjari, Alireza, Choucair, Khalil, Sadeghipour, Arezoo, Saeed, Azhar, Saeed, Anwaar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487099/
https://www.ncbi.nlm.nih.gov/pubmed/37686570
http://dx.doi.org/10.3390/cancers15174294
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author Tojjari, Alireza
Choucair, Khalil
Sadeghipour, Arezoo
Saeed, Azhar
Saeed, Anwaar
author_facet Tojjari, Alireza
Choucair, Khalil
Sadeghipour, Arezoo
Saeed, Azhar
Saeed, Anwaar
author_sort Tojjari, Alireza
collection PubMed
description SIMPLE SUMMARY: In our review, we investigate polyunsaturated fatty acids, or PUFAs for short, and their potential role in preventing and treating colorectal cancer (CRC). We are inspired to do this research because CRC is becoming more common, and we are always looking for new ways to tackle it. We aim to shed light on how PUFAs, known for their anti-inflammatory and immune-boosting properties, might influence CRC. By understanding more about how PUFAs interact with CRC on a molecular level, we could open up new dietary strategies and treatments. This could mean better patient outcomes and a powerful new tool in our fight against CRC. ABSTRACT: Colorectal cancer (CRC) remains a leading cause of death from cancer worldwide, with increasing incidence in the Western world. Diet has become the focus of research as a significant risk factor for CRC occurrence, and the role of dietary polyunsaturated fatty acids (PUFAs) has become an area of interest given their potential role in modulating inflammation, particularly in the pro-carcinogenic inflammatory environment of the colon. This work reviews the main types of PUFAs, their characteristics, structure, and physiologic role. We then highlight their potential role in preventing CRC, their signaling function vis-à-vis tumorigenic signaling, and their subsequent potential role in modulating response to different treatment modalities. We review pre-clinical and clinical data and discuss their potential use as adjunct therapies to currently existing treatment modalities. Given our understanding of PUFAs’ immune and inflammation modulatory effects, we explore the possible combination of PUFAs with immune checkpoint inhibitors and other targeted therapies.
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spelling pubmed-104870992023-09-09 Anti-Inflammatory and Immune Properties of Polyunsaturated Fatty Acids (PUFAs) and Their Impact on Colorectal Cancer (CRC) Prevention and Treatment Tojjari, Alireza Choucair, Khalil Sadeghipour, Arezoo Saeed, Azhar Saeed, Anwaar Cancers (Basel) Review SIMPLE SUMMARY: In our review, we investigate polyunsaturated fatty acids, or PUFAs for short, and their potential role in preventing and treating colorectal cancer (CRC). We are inspired to do this research because CRC is becoming more common, and we are always looking for new ways to tackle it. We aim to shed light on how PUFAs, known for their anti-inflammatory and immune-boosting properties, might influence CRC. By understanding more about how PUFAs interact with CRC on a molecular level, we could open up new dietary strategies and treatments. This could mean better patient outcomes and a powerful new tool in our fight against CRC. ABSTRACT: Colorectal cancer (CRC) remains a leading cause of death from cancer worldwide, with increasing incidence in the Western world. Diet has become the focus of research as a significant risk factor for CRC occurrence, and the role of dietary polyunsaturated fatty acids (PUFAs) has become an area of interest given their potential role in modulating inflammation, particularly in the pro-carcinogenic inflammatory environment of the colon. This work reviews the main types of PUFAs, their characteristics, structure, and physiologic role. We then highlight their potential role in preventing CRC, their signaling function vis-à-vis tumorigenic signaling, and their subsequent potential role in modulating response to different treatment modalities. We review pre-clinical and clinical data and discuss their potential use as adjunct therapies to currently existing treatment modalities. Given our understanding of PUFAs’ immune and inflammation modulatory effects, we explore the possible combination of PUFAs with immune checkpoint inhibitors and other targeted therapies. MDPI 2023-08-28 /pmc/articles/PMC10487099/ /pubmed/37686570 http://dx.doi.org/10.3390/cancers15174294 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tojjari, Alireza
Choucair, Khalil
Sadeghipour, Arezoo
Saeed, Azhar
Saeed, Anwaar
Anti-Inflammatory and Immune Properties of Polyunsaturated Fatty Acids (PUFAs) and Their Impact on Colorectal Cancer (CRC) Prevention and Treatment
title Anti-Inflammatory and Immune Properties of Polyunsaturated Fatty Acids (PUFAs) and Their Impact on Colorectal Cancer (CRC) Prevention and Treatment
title_full Anti-Inflammatory and Immune Properties of Polyunsaturated Fatty Acids (PUFAs) and Their Impact on Colorectal Cancer (CRC) Prevention and Treatment
title_fullStr Anti-Inflammatory and Immune Properties of Polyunsaturated Fatty Acids (PUFAs) and Their Impact on Colorectal Cancer (CRC) Prevention and Treatment
title_full_unstemmed Anti-Inflammatory and Immune Properties of Polyunsaturated Fatty Acids (PUFAs) and Their Impact on Colorectal Cancer (CRC) Prevention and Treatment
title_short Anti-Inflammatory and Immune Properties of Polyunsaturated Fatty Acids (PUFAs) and Their Impact on Colorectal Cancer (CRC) Prevention and Treatment
title_sort anti-inflammatory and immune properties of polyunsaturated fatty acids (pufas) and their impact on colorectal cancer (crc) prevention and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487099/
https://www.ncbi.nlm.nih.gov/pubmed/37686570
http://dx.doi.org/10.3390/cancers15174294
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