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A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health
PURPOSE: Our purpose was to examine the effects of 2 yr of creatine monohydrate supplementation and exercise on bone health in postmenopausal women. METHODS: Two hundred and thirty-seven postmenopausal women (mean age, 59 yr) were randomized to receive creatine (0.14 g·kg(−1)·d(−1)) or placebo durin...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487398/ https://www.ncbi.nlm.nih.gov/pubmed/37144634 http://dx.doi.org/10.1249/MSS.0000000000003202 |
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author | CHILIBECK, PHILIP D. CANDOW, DARREN G. GORDON, JULIANNE J. DUFF, WHITNEY R. D. MASON, RILEY SHAW, KEELY TAYLOR-GJEVRE, REGINA NAIR, BINDU ZELLO, GORDON A. |
author_facet | CHILIBECK, PHILIP D. CANDOW, DARREN G. GORDON, JULIANNE J. DUFF, WHITNEY R. D. MASON, RILEY SHAW, KEELY TAYLOR-GJEVRE, REGINA NAIR, BINDU ZELLO, GORDON A. |
author_sort | CHILIBECK, PHILIP D. |
collection | PubMed |
description | PURPOSE: Our purpose was to examine the effects of 2 yr of creatine monohydrate supplementation and exercise on bone health in postmenopausal women. METHODS: Two hundred and thirty-seven postmenopausal women (mean age, 59 yr) were randomized to receive creatine (0.14 g·kg(−1)·d(−1)) or placebo during a resistance training (3 d·wk(−1)) and walking (6 d·wk(−1)) program for 2 yr. Our primary outcome was the femoral neck bone mineral density (BMD), with lumbar spine BMD and proximal femur geometric properties as the secondary outcomes. RESULTS: Compared with placebo, creatine supplementation had no effect on BMD of the femoral neck (creatine: 0.725 ± 0.110 to 0.712 ± 0.100 g·cm(−2); placebo: 0.721 ± 0.102 to 0.706 ± 0.097 g·cm(−2)), total hip (creatine: 0.879 ± 0.118 to 0.872 ± 0.114 g·cm(−2); placebo: 0.881 ± 0.111 to 0.873 ± 0.109 g·cm(−2)), or lumbar spine (creatine: 0.932 ± 0.133 to 0.925 ± 0.131 g·cm(−2); placebo: 0.923 ± 0.145 to 0.915 ± 0.143 g·cm(−2)). Creatine significantly maintained section modulus (1.35 ± 0.29 to 1.34 ± 0.26 vs 1.34 ± 0.25 to 1.28 ± 0.23 cm(3) (placebo), P = 0.0011), predictive of bone bending strength, and buckling ratio (10.8 ± 2.6 to 11.1 ± 2.2 vs 11.0 ± 2.6 to 11.6 ± 2.7 (placebo), P = 0.011), predictive of reduced cortical bending under compressive loads, at the narrow part of the femoral neck. Creatine reduced walking time over 80 m (48.6 ± 5.6 to 47.1 ± 5.4 vs 48.3 ± 4.5 to 48.2 ± 4.9 s (placebo), P = 0.0008) but had no effect on muscular strength (i.e., one-repetition maximum) during bench press (32.1 ± 12.7 to 42.6 ± 14.1 vs 30.6 ± 10.9 to 41.4 ± 14 kg (placebo)) and hack squat (57.6 ± 21.6 to 84.4 ± 28.1 vs 56.6 ± 24.0 to 82.7 ± 25.0 kg (placebo)). In the subanalysis of valid completers, creatine increased lean tissue mass compared with placebo (40.8 ± 5.7 to 43.1 ± 5.9 vs 40.4 ± 5.3 to 42.0 ± 5.2 kg (placebo), P = 0.046). CONCLUSIONS: Two years of creatine supplementation and exercise in postmenopausal women had no effect on BMD; yet, it improved some bone geometric properties at the proximal femur. |
format | Online Article Text |
id | pubmed-10487398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-104873982023-09-09 A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health CHILIBECK, PHILIP D. CANDOW, DARREN G. GORDON, JULIANNE J. DUFF, WHITNEY R. D. MASON, RILEY SHAW, KEELY TAYLOR-GJEVRE, REGINA NAIR, BINDU ZELLO, GORDON A. Med Sci Sports Exerc Clinical Sciences PURPOSE: Our purpose was to examine the effects of 2 yr of creatine monohydrate supplementation and exercise on bone health in postmenopausal women. METHODS: Two hundred and thirty-seven postmenopausal women (mean age, 59 yr) were randomized to receive creatine (0.14 g·kg(−1)·d(−1)) or placebo during a resistance training (3 d·wk(−1)) and walking (6 d·wk(−1)) program for 2 yr. Our primary outcome was the femoral neck bone mineral density (BMD), with lumbar spine BMD and proximal femur geometric properties as the secondary outcomes. RESULTS: Compared with placebo, creatine supplementation had no effect on BMD of the femoral neck (creatine: 0.725 ± 0.110 to 0.712 ± 0.100 g·cm(−2); placebo: 0.721 ± 0.102 to 0.706 ± 0.097 g·cm(−2)), total hip (creatine: 0.879 ± 0.118 to 0.872 ± 0.114 g·cm(−2); placebo: 0.881 ± 0.111 to 0.873 ± 0.109 g·cm(−2)), or lumbar spine (creatine: 0.932 ± 0.133 to 0.925 ± 0.131 g·cm(−2); placebo: 0.923 ± 0.145 to 0.915 ± 0.143 g·cm(−2)). Creatine significantly maintained section modulus (1.35 ± 0.29 to 1.34 ± 0.26 vs 1.34 ± 0.25 to 1.28 ± 0.23 cm(3) (placebo), P = 0.0011), predictive of bone bending strength, and buckling ratio (10.8 ± 2.6 to 11.1 ± 2.2 vs 11.0 ± 2.6 to 11.6 ± 2.7 (placebo), P = 0.011), predictive of reduced cortical bending under compressive loads, at the narrow part of the femoral neck. Creatine reduced walking time over 80 m (48.6 ± 5.6 to 47.1 ± 5.4 vs 48.3 ± 4.5 to 48.2 ± 4.9 s (placebo), P = 0.0008) but had no effect on muscular strength (i.e., one-repetition maximum) during bench press (32.1 ± 12.7 to 42.6 ± 14.1 vs 30.6 ± 10.9 to 41.4 ± 14 kg (placebo)) and hack squat (57.6 ± 21.6 to 84.4 ± 28.1 vs 56.6 ± 24.0 to 82.7 ± 25.0 kg (placebo)). In the subanalysis of valid completers, creatine increased lean tissue mass compared with placebo (40.8 ± 5.7 to 43.1 ± 5.9 vs 40.4 ± 5.3 to 42.0 ± 5.2 kg (placebo), P = 0.046). CONCLUSIONS: Two years of creatine supplementation and exercise in postmenopausal women had no effect on BMD; yet, it improved some bone geometric properties at the proximal femur. Lippincott Williams & Wilkins 2023-10 2023-05-05 /pmc/articles/PMC10487398/ /pubmed/37144634 http://dx.doi.org/10.1249/MSS.0000000000003202 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Clinical Sciences CHILIBECK, PHILIP D. CANDOW, DARREN G. GORDON, JULIANNE J. DUFF, WHITNEY R. D. MASON, RILEY SHAW, KEELY TAYLOR-GJEVRE, REGINA NAIR, BINDU ZELLO, GORDON A. A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health |
title | A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health |
title_full | A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health |
title_fullStr | A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health |
title_full_unstemmed | A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health |
title_short | A 2-yr Randomized Controlled Trial on Creatine Supplementation during Exercise for Postmenopausal Bone Health |
title_sort | 2-yr randomized controlled trial on creatine supplementation during exercise for postmenopausal bone health |
topic | Clinical Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487398/ https://www.ncbi.nlm.nih.gov/pubmed/37144634 http://dx.doi.org/10.1249/MSS.0000000000003202 |
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