The Dipeptide Gly-Pro (GP), Derived from Hibiscus sabdariffa, Exhibits Potent Antifibrotic Effects by Regulating the TGF-β1-ATF4-Serine/Glycine Biosynthesis Pathway

TGF-β1, a key fibrotic cytokine, enhances both the expression and translocation of the activating transcriptional factor 4 (ATF4) and activates the serine/glycine biosynthesis pathway, which is crucial for augmenting collagen production. Targeting the TGF-β1-ATF4-serine/glycine biosynthesis pathway...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, HaiVin, Jang, YoungSu, Ryu, JaeSang, Seo, DaHye, Lee, Sak, Choi, SungSoo, Kim, DongHyun, Moh, SangHyun, Shin, JungU
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487435/
https://www.ncbi.nlm.nih.gov/pubmed/37686422
http://dx.doi.org/10.3390/ijms241713616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487435/
https://www.ncbi.nlm.nih.gov/pubmed/37686422
http://dx.doi.org/10.3390/ijms241713616

Ejemplares similares