Targeting AHR Increases Pancreatic Cancer Cell Sensitivity to Gemcitabine through the ELAVL1-DCK Pathway

The aryl hydrocarbon receptor (AHR) is a transcription factor that is commonly upregulated in pancreatic ductal adenocarcinoma (PDAC). AHR hinders the shuttling of human antigen R (ELAVL1) from the nucleus to the cytoplasm, where it stabilises its target messenger RNAs (mRNAs) and enhances protein e...

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Detalles Bibliográficos
Autores principales: Stukas, Darius, Jasukaitiene, Aldona, Bartkeviciene, Arenida, Matthews, Jason, Maimets, Toivo, Teino, Indrek, Jaudzems, Kristaps, Gulbinas, Antanas, Dambrauskas, Zilvinas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487468/
https://www.ncbi.nlm.nih.gov/pubmed/37685961
http://dx.doi.org/10.3390/ijms241713155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487468/
https://www.ncbi.nlm.nih.gov/pubmed/37685961
http://dx.doi.org/10.3390/ijms241713155

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