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Targeting AHR Increases Pancreatic Cancer Cell Sensitivity to Gemcitabine through the ELAVL1-DCK Pathway

The aryl hydrocarbon receptor (AHR) is a transcription factor that is commonly upregulated in pancreatic ductal adenocarcinoma (PDAC). AHR hinders the shuttling of human antigen R (ELAVL1) from the nucleus to the cytoplasm, where it stabilises its target messenger RNAs (mRNAs) and enhances protein e...

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Detalles Bibliográficos
Autores principales:	Stukas, Darius, Jasukaitiene, Aldona, Bartkeviciene, Arenida, Matthews, Jason, Maimets, Toivo, Teino, Indrek, Jaudzems, Kristaps, Gulbinas, Antanas, Dambrauskas, Zilvinas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487468/ https://www.ncbi.nlm.nih.gov/pubmed/37685961 http://dx.doi.org/10.3390/ijms241713155

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