A Genetically Encoded Dark-to-Bright Biosensor for Visualisation of Granzyme-Mediated Cytotoxicity

Granzyme B (GZMB) is a key enzyme released by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells to induce apoptosis in target cells. We designed a novel fluorogenic biosensor which is able to assess GZMB activity in a specific and sensitive manner. This cleavage-responsive sensor for T cel...

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Detalles Bibliográficos
Autores principales: Bednar, Christopher, Kübel, Sabrina, Cordsmeier, Arne, Scholz, Brigitte, Menschikowski, Hanna, Ensser, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487497/
https://www.ncbi.nlm.nih.gov/pubmed/37686395
http://dx.doi.org/10.3390/ijms241713589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487497/
https://www.ncbi.nlm.nih.gov/pubmed/37686395
http://dx.doi.org/10.3390/ijms241713589

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