Conservative Tryptophan Residue in the Vicinity of an Active Site of the M15 Family l,d-Peptidases: A Key Element in the Catalysis

Bioinformatics analysis of the sequences of orthologous zinc-containing peptidases of the M15_C subfamily revealed the presence of a conserved tryptophan residue near the active site, which is not involved in the formation of the protein core. Site-directed mutagenesis of this Trp114/109 residue usi...

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Detalles Bibliográficos
Autores principales: Mikoulinskaia, Galina V., Prokhorov, Dmitry A., Chernyshov, Sergei V., Sitnikova, Daria S., Arakelian, Arina G., Uversky, Vladimir N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487532/
https://www.ncbi.nlm.nih.gov/pubmed/37686055
http://dx.doi.org/10.3390/ijms241713249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487532/
https://www.ncbi.nlm.nih.gov/pubmed/37686055
http://dx.doi.org/10.3390/ijms241713249

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