Evaluating the Cysteine-Rich and Catalytic Subdomains of Human Tyrosinase and OCA1-Related Mutants Using 1 μs Molecular Dynamics Simulation

The inherited disorder oculocutaneous albinism type 1 (OCA1) is caused by mutations in the TYR gene encoding tyrosinase (Tyr), an enzyme essential to producing pigments throughout the human body. The intramelanosomal domain of Tyr consists of the cysteine-rich and tyrosinase catalytic subdomains, wh...

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Detalles Bibliográficos
Autores principales: Woods, Taariq, Sergeev, Yuri V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487697/
https://www.ncbi.nlm.nih.gov/pubmed/37685839
http://dx.doi.org/10.3390/ijms241713032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487697/
https://www.ncbi.nlm.nih.gov/pubmed/37685839
http://dx.doi.org/10.3390/ijms241713032

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