Inhibition of Notch Signaling Enhances Antitumor Activity of Histone Deacetylase Inhibitor LAQ824

As a novel histone deacetylase inhibitor (HDACi), LAQ824 (LAQ) effectively inhibits the proliferation of hematological malignancies and solid tumors. However, phase II trials of LAQ in solid tumors were terminated due to dose-dependent toxicity. Furthermore, LAQ has been shown to induce the activati...

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Detalles Bibliográficos
Autores principales: Mei, Qinglang, Xu, Xiaohan, Gao, Danling, Xu, Yuting, Yang, Jinbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487749/
https://www.ncbi.nlm.nih.gov/pubmed/37686467
http://dx.doi.org/10.3390/ijms241713660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487749/
https://www.ncbi.nlm.nih.gov/pubmed/37686467
http://dx.doi.org/10.3390/ijms241713660

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