Genetic Variation in miR-27a Is Associated with Fluoropyrimidine-Associated Toxicity in Patients with Dihydropyrimidine Dehydrogenase Variants after Genotype-Guided Dose Reduction

Dihydropyrimidine dehydrogenase (DPYD) is the rate-limiting enzyme involved in the metabolism of fluoropyrimidine-based chemotherapy. However, single-nucleotide variants (SNVs) in DPYD only partially explain fluoropyrimidine-induced toxicity. The expression of DPYD has previously been shown to be re...

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Detalles Bibliográficos
Autores principales: Medwid, Samantha, Wigle, Theodore J., Ross, Cameron, Kim, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487873/
https://www.ncbi.nlm.nih.gov/pubmed/37686089
http://dx.doi.org/10.3390/ijms241713284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487873/
https://www.ncbi.nlm.nih.gov/pubmed/37686089
http://dx.doi.org/10.3390/ijms241713284

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