Could the Oxidation of α1-Antitrypsin Prevent the Binding of Human Neutrophil Elastase in COVID-19 Patients?

Human neutrophil elastase (HNE) is involved in SARS-CoV-2 virulence and plays a pivotal role in lung infection of patients infected by COVID-19. In healthy individuals, HNE activity is balanced by α1-antitrypsin (AAT). This is a 52 kDa glycoprotein, mainly produced and secreted by hepatocytes, that...

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Detalles Bibliográficos
Autores principales: D’Amato, Maura, Campagnoli, Monica, Iadarola, Paolo, Bignami, Paola Margherita, Fumagalli, Marco, Chiarelli, Laurent Roberto, Stelitano, Giovanni, Meloni, Federica, Linciano, Pasquale, Collina, Simona, Pietrocola, Giampiero, Vertui, Valentina, Aliberti, Anna, Fossali, Tommaso, Viglio, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488172/
https://www.ncbi.nlm.nih.gov/pubmed/37686340
http://dx.doi.org/10.3390/ijms241713533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488172/
https://www.ncbi.nlm.nih.gov/pubmed/37686340
http://dx.doi.org/10.3390/ijms241713533

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