Deacetylated Sialic Acid Sensitizes Lung and Colon Cancers to Novel Cucurbitacin-Inspired Estrone Epidermal Growth Factor Receptor (EGFR) Inhibitor Analogs

Cancers utilize sugar residues such as sialic acids (Sia) to improve their ability to survive. Sia presents a variety of functional group alterations, including O-acetylation on the C6 hydroxylated tail. Previously, sialylation has been reported to suppress EGFR activation and increase cancer cell s...

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Detalles Bibliográficos
Autores principales: Anim, Mathias T., Tuffour, Isaac, Willis, Rylan, Schell, Matthew, Ostlund, Trevor, Mahnashi, Mater H., Halaweish, Fathi, Willand-Charnley, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488366/
https://www.ncbi.nlm.nih.gov/pubmed/37687086
http://dx.doi.org/10.3390/molecules28176257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488366/
https://www.ncbi.nlm.nih.gov/pubmed/37687086
http://dx.doi.org/10.3390/molecules28176257

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