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Ligand-Free Signaling of G-Protein-Coupled Receptors: Physiology, Pharmacology, and Genetics
G-protein-coupled receptors (GPCRs) are ubiquitous sensors and regulators of cellular functions. Each GPCR exists in complex aggregates with multiple resting and active conformations. Designed to detect weak stimuli, GPCRs can also activate spontaneously, resulting in basal ligand-free signaling. Ag...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489045/ https://www.ncbi.nlm.nih.gov/pubmed/37687205 http://dx.doi.org/10.3390/molecules28176375 |