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Threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: Evidence from the NHANES

Flavonoids have been shown to be beneficial in a variety of inflammatory and metabolic diseases because of their anti-inflammatory and antioxidant properties. However, previous epidemiological studies have only demonstrated a negative correlation between flavonoid intake on inflammatory markers, and...

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Autores principales: Wan, Huijuan, Huang, Xiongjie, Xu, Yunhua, Liu, Mingjiang, Wang, Jiusong, Xiao, Meimei, He, Zhixiang, Song, Jiangang, Xiao, Xiangjun, Ou, Jun, Tang, Zetao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489350/
https://www.ncbi.nlm.nih.gov/pubmed/37682186
http://dx.doi.org/10.1097/MD.0000000000034665
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author Wan, Huijuan
Huang, Xiongjie
Xu, Yunhua
Liu, Mingjiang
Wang, Jiusong
Xiao, Meimei
He, Zhixiang
Song, Jiangang
Xiao, Xiangjun
Ou, Jun
Tang, Zetao
author_facet Wan, Huijuan
Huang, Xiongjie
Xu, Yunhua
Liu, Mingjiang
Wang, Jiusong
Xiao, Meimei
He, Zhixiang
Song, Jiangang
Xiao, Xiangjun
Ou, Jun
Tang, Zetao
author_sort Wan, Huijuan
collection PubMed
description Flavonoids have been shown to be beneficial in a variety of inflammatory and metabolic diseases because of their anti-inflammatory and antioxidant properties. However, previous epidemiological studies have only demonstrated a negative correlation between flavonoid intake on inflammatory markers, and the optimal intake of dietary flavonoids and subclasses in terms of dietary anti-inflammatory efficacy remains undetermined. This study was based on 3 cycles (2007–2010, 2017–2018) of the National Health and Nutrition Examination Survey and the corresponding expanded flavonoid database. Weighted multiple linear regression was used to assess linear relationships between flavonoid intake and Dietary inflammation index (DII). Smoothed curve fit and a generalized additive model were used to investigate the nonlinear relationships and threshold effects, the 2-tailed linear regression model was used to find potential inflection points. A total of 12,724 adults were included in the study. After adjusting for potential confounders, flavonoid intake was significantly associated with DII, with the strongest negative association effect for flavonols (−0.40 [−0.45, −0.35]). In subgroup analyses stratified by sex, race, age, body mass index, education levels, and diabetes, flavonol intake maintained a significant negative linear correlation with DII. In addition, we found significant nonlinear relationships (L-shaped relationships) and threshold effects between total flavonoids, flavan-3-ols, and flavanols and DII, with inflection points of 437.65 mg/days, 157.79 mg/days, and 46.36 mg/days, respectively. Our results suggest a threshold for the dietary anti-inflammatory capacity of flavonoid intake in U.S. adults.
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spelling pubmed-104893502023-09-09 Threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: Evidence from the NHANES Wan, Huijuan Huang, Xiongjie Xu, Yunhua Liu, Mingjiang Wang, Jiusong Xiao, Meimei He, Zhixiang Song, Jiangang Xiao, Xiangjun Ou, Jun Tang, Zetao Medicine (Baltimore) 4400 Flavonoids have been shown to be beneficial in a variety of inflammatory and metabolic diseases because of their anti-inflammatory and antioxidant properties. However, previous epidemiological studies have only demonstrated a negative correlation between flavonoid intake on inflammatory markers, and the optimal intake of dietary flavonoids and subclasses in terms of dietary anti-inflammatory efficacy remains undetermined. This study was based on 3 cycles (2007–2010, 2017–2018) of the National Health and Nutrition Examination Survey and the corresponding expanded flavonoid database. Weighted multiple linear regression was used to assess linear relationships between flavonoid intake and Dietary inflammation index (DII). Smoothed curve fit and a generalized additive model were used to investigate the nonlinear relationships and threshold effects, the 2-tailed linear regression model was used to find potential inflection points. A total of 12,724 adults were included in the study. After adjusting for potential confounders, flavonoid intake was significantly associated with DII, with the strongest negative association effect for flavonols (−0.40 [−0.45, −0.35]). In subgroup analyses stratified by sex, race, age, body mass index, education levels, and diabetes, flavonol intake maintained a significant negative linear correlation with DII. In addition, we found significant nonlinear relationships (L-shaped relationships) and threshold effects between total flavonoids, flavan-3-ols, and flavanols and DII, with inflection points of 437.65 mg/days, 157.79 mg/days, and 46.36 mg/days, respectively. Our results suggest a threshold for the dietary anti-inflammatory capacity of flavonoid intake in U.S. adults. Lippincott Williams & Wilkins 2023-09-08 /pmc/articles/PMC10489350/ /pubmed/37682186 http://dx.doi.org/10.1097/MD.0000000000034665 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 4400
Wan, Huijuan
Huang, Xiongjie
Xu, Yunhua
Liu, Mingjiang
Wang, Jiusong
Xiao, Meimei
He, Zhixiang
Song, Jiangang
Xiao, Xiangjun
Ou, Jun
Tang, Zetao
Threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: Evidence from the NHANES
title Threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: Evidence from the NHANES
title_full Threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: Evidence from the NHANES
title_fullStr Threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: Evidence from the NHANES
title_full_unstemmed Threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: Evidence from the NHANES
title_short Threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: Evidence from the NHANES
title_sort threshold effects and inflection points of flavonoid intake in dietary anti-inflammatory effects: evidence from the nhanes
topic 4400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489350/
https://www.ncbi.nlm.nih.gov/pubmed/37682186
http://dx.doi.org/10.1097/MD.0000000000034665
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