Exploration of Baicalein-Core Derivatives as Potent Antifungal Agents: SAR and Mechanism Insights

HIGHLIGHTS: What are the main findings? Baicalein-Core Derivatives were designed and synthesized as Potent Anti-Fluconazole-resistant fungal Agents. O-dihydroxyls and vic-trihydroxy groups on either the A ring or B ring of flavones play a crucial role. MoA: Inhibit hypha formation; Little effect on...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Heyang, Yang, Niao, Li, Wei, Peng, Xuemi, Dong, Jiaxiao, Jiang, Yuanying, Yan, Lan, Zhang, Dazhi, Jin, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489750/
https://www.ncbi.nlm.nih.gov/pubmed/37687172
http://dx.doi.org/10.3390/molecules28176340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489750/
https://www.ncbi.nlm.nih.gov/pubmed/37687172
http://dx.doi.org/10.3390/molecules28176340

Ejemplares similares