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Exploration of Baicalein-Core Derivatives as Potent Antifungal Agents: SAR and Mechanism Insights

HIGHLIGHTS: What are the main findings? Baicalein-Core Derivatives were designed and synthesized as Potent Anti-Fluconazole-resistant fungal Agents. O-dihydroxyls and vic-trihydroxy groups on either the A ring or B ring of flavones play a crucial role. MoA: Inhibit hypha formation; Little effect on...

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Detalles Bibliográficos
Autores principales:	Zhou, Heyang, Yang, Niao, Li, Wei, Peng, Xuemi, Dong, Jiaxiao, Jiang, Yuanying, Yan, Lan, Zhang, Dazhi, Jin, Yongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489750/ https://www.ncbi.nlm.nih.gov/pubmed/37687172 http://dx.doi.org/10.3390/molecules28176340

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