Synthesis and In Vitro Anticancer Activity of Novel 4-Aryl-3-(4-methoxyphenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridines Arrest Cell Cycle and Induce Cell Apoptosis by Inhibiting CDK2 and/or CDK9

Two series of pyrazolo[3,4-b]pyridine derivatives, 9a–h and 14a–h, are synthesized and evaluated for their anti-cancer potency towards Hela, MCF7, and HCT-116 cancer cell lines. Compound 9a showed the highest anticancer activity with IC(50) = 2.59 µM against Hela when compared with doxorubicin (IC(5...

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Detalles Bibliográficos
Autores principales: Almansour, Basma S., Binjubair, Faizah A., Abdel-Aziz, Alaa A.-M., Al-Rashood, Sara T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490123/
https://www.ncbi.nlm.nih.gov/pubmed/37687256
http://dx.doi.org/10.3390/molecules28176428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490123/
https://www.ncbi.nlm.nih.gov/pubmed/37687256
http://dx.doi.org/10.3390/molecules28176428

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