Oxidation of the Platinum(II) Anticancer Agent [Pt{(p-BrC(6)F(4))NCH(2)CH(2)NEt(2)}Cl(py)] to Platinum(IV) Complexes by Hydrogen Peroxide

Pt(IV) coordination complexes are of interest as prodrugs of Pt(II) anticancer agents, as they can avoid deactivation pathways owing to their inert nature. Here, we report the oxidation of the antitumor agent [Pt(II)(p-BrC(6)F(4))NCH(2)CH(2)NEt(2)}Cl(py)], 1 (py = pyridine) to dihydroxidoplatinum(IV...

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Detalles Bibliográficos
Autores principales: Ojha, Ruchika, Junk, Peter C., Bond, Alan M., Deacon, Glen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490441/
https://www.ncbi.nlm.nih.gov/pubmed/37687231
http://dx.doi.org/10.3390/molecules28176402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490441/
https://www.ncbi.nlm.nih.gov/pubmed/37687231
http://dx.doi.org/10.3390/molecules28176402

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