Preparation and Characterization of Spray-Dried Hybrid Nanocrystal–Amorphous Solid Dispersions (HyNASDs) for Supersaturation Enhancement of a Slowly Crystallizing Drug

We prepared hybrid nanocrystal–amorphous solid dispersions (HyNASDs) to examine their supersaturation capability in the release of a poorly soluble drug, itraconazole (ITZ), a slow crystallizer during dissolution. The HyNASD formulations included a polymer (HPC: hydroxypropyl cellulose, Sol: Soluplu...

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Detalles Bibliográficos
Autores principales: Rahman, Mahbubur, Radgman, Keanu, Tarabokija, James, Ahmad, Stephanie, Bilgili, Ecevit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490532/
https://www.ncbi.nlm.nih.gov/pubmed/37686927
http://dx.doi.org/10.3390/nano13172419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490532/
https://www.ncbi.nlm.nih.gov/pubmed/37686927
http://dx.doi.org/10.3390/nano13172419

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