Helicase-like transcription factor (HLTF)-deleted CDX/TME model of colorectal cancer increased transcription of oxidative phosphorylation genes and diverted glycolysis to boost S-glutathionylation in lymphatic intravascular metastatic niches

Helicase-like transcription factor (HLTF) also known as SMARCA3, protects genome integrity. A tumor suppressor, HLTF is expressed in tumor cells but not in the tumor microenvironment (TME) in early-stage colorectal cancer (CRC). With disease progression, there is high concordance between epigenetic...

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Detalles Bibliográficos
Autores principales: Martinez-Marin, Dalia, Helmer, Rebecca A., Kaur, Gurvinder, Washburn, Rachel L., Martinez-Zaguilan, Raul, Sennone, Souad R., Dufour, Jannette M., Chilton, Beverly S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490896/
https://www.ncbi.nlm.nih.gov/pubmed/37682902
http://dx.doi.org/10.1371/journal.pone.0291023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490896/
https://www.ncbi.nlm.nih.gov/pubmed/37682902
http://dx.doi.org/10.1371/journal.pone.0291023

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