PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination

In multiple sclerosis (MS), microglia and macrophages within the central nervous system (CNS) play an important role in determining the balance between myelin repair and demyelination/neurodegeneration. Phagocytic and regenerative functions of these CNS innate immune cells support remyelination, whe...

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Detalles Bibliográficos
Autores principales: Gharibani, Payam, Abramson, Efrat, Shanmukha, Shruthi, Smith, Matthew D., Godfrey, Wesley H., Lee, Judy J., Hu, Jingwen, Baydyuk, Maryna, Dorion, Marie-France, Deng, Xiaojing, Guo, Yu, Hwang, Soonmyung, Huang, Jeffrey K., Calabresi, Peter A., Kornberg, Michael D., Kim, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491095/
https://www.ncbi.nlm.nih.gov/pubmed/37693473
http://dx.doi.org/10.1101/2023.08.28.555084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491095/
https://www.ncbi.nlm.nih.gov/pubmed/37693473
http://dx.doi.org/10.1101/2023.08.28.555084

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