FOXC1 and FOXC2 maintain mitral valve endothelial cell junctions, extracellular matrix, and lymphatic vessels to prevent myxomatous degeneration

BACKGROUND: Mitral valve (MV) disease including myxomatous degeneration is the most common form of valvular heart disease with an age-dependent frequency. Genetic evidence indicates mutations of the transcription factor FOXC1 are associated with MV defects, including mitral valve regurgitation. In t...

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Detalles Bibliográficos
Autores principales: Tan, Can, Kurup, Shreya, Dyakiv, Yaryna, Kume, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491158/
https://www.ncbi.nlm.nih.gov/pubmed/37693499
http://dx.doi.org/10.1101/2023.08.30.555455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491158/
https://www.ncbi.nlm.nih.gov/pubmed/37693499
http://dx.doi.org/10.1101/2023.08.30.555455

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