Myelin dystrophy in the aging prefrontal cortex leads to impaired signal transmission and working memory decline: a multiscale computational study

Normal aging leads to myelin alternations in the rhesus monkey dorsolateral prefrontal cortex (dlPFC), which are often correlated with cognitive impairment. It is hypothesized that remyelination with shorter and thinner myelin sheaths partially compensates for myelin degradation, but computational m...

Descripción completa

Detalles Bibliográficos
Autores principales: Ibañez, Sara, Sengupta, Nilapratim, Luebke, Jennifer I., Wimmer, Klaus, Weaver, Christina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491254/
https://www.ncbi.nlm.nih.gov/pubmed/37693412
http://dx.doi.org/10.1101/2023.08.30.555476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491254/
https://www.ncbi.nlm.nih.gov/pubmed/37693412
http://dx.doi.org/10.1101/2023.08.30.555476

Ejemplares similares