ω-Phonetoxins inhibit voltage-gated calcium Ca(V)2.2 ion channel splice isoforms of dorsal root ganglia

Cell-specific alternative splicing of Cacna1b pre-mRNA generates functionally distinct voltage-gated Ca(V)2.2 channels. Ca(V)2.2 channels mediate the release of glutamate from nociceptor termini in the dorsal horn spinal cord and they are implicated in chronic pain. One alternatively spliced exon in...

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Detalles Bibliográficos
Autores principales: Castro-Junior, Célio, Gomez, Marcus Vinícius, Borges, Marcia Helena, Lipscombe, Diane, Andrade, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491260/
https://www.ncbi.nlm.nih.gov/pubmed/37693414
http://dx.doi.org/10.1101/2023.08.29.555337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491260/
https://www.ncbi.nlm.nih.gov/pubmed/37693414
http://dx.doi.org/10.1101/2023.08.29.555337

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