Human gut metagenomic mining reveals an untapped source of peptide antibiotics

Drug-resistant bacteria are outpacing traditional antibiotic discovery efforts. Here, we computationally mined 444,054 families of putative small proteins from 1,773 human gut metagenomes, identifying 323 peptide antibiotics encoded in small open reading frames (smORFs). To test our computational pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Torres, Marcelo D. T., Brooks, Erin, Cesaro, Angela, Sberro, Hila, Nicolaou, Cosmos, Bhatt, Ami S., de la Fuente-Nunez, Cesar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491270/
https://www.ncbi.nlm.nih.gov/pubmed/37693399
http://dx.doi.org/10.1101/2023.08.31.555711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491270/
https://www.ncbi.nlm.nih.gov/pubmed/37693399
http://dx.doi.org/10.1101/2023.08.31.555711

Ejemplares similares