Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation

Systemic blood coagulation accompanies inflammation during severe infection like sepsis and COVID. We've previously established a link between pyroptosis, a vital defense mechanism against infection, and coagulopathy. During pyroptosis, the formation of gasdermin-D (GSDMD) pores on the plasma m...

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Detalles Bibliográficos
Autores principales: Cui, Jian, Li, Hua, Zhang, Guoying, Zhang, Yan, Yang, Ling, Sim, Martha M.S., Wood, Jeremy P., Wei, Yinan, Li, Zhenyu, Wu, Congqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491273/
https://www.ncbi.nlm.nih.gov/pubmed/37693519
http://dx.doi.org/10.1101/2023.08.30.555561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491273/
https://www.ncbi.nlm.nih.gov/pubmed/37693519
http://dx.doi.org/10.1101/2023.08.30.555561

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