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HCN channels sense temperature and determine heart rate responses to heat

Heart rate increases with heat, [1–3] constituting a fundamental physiological relationship in vertebrates. Each normal heartbeat is initiated by an action potential generated in a sinoatrial nodal pacemaker cell. Pacemaker cells are enriched with hyperpolarization activated cyclic nucleotide-gated...

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Detalles Bibliográficos
Autores principales: Wu, Yuejin, Wang, Qinchuan, Granger, Jonathan, Gaido, Oscar Reyes, Aguilar, Eric Nunez, Ludwig, Andreas, Moroni, Anna, Bianchet, Mario A., Anderson, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491304/
https://www.ncbi.nlm.nih.gov/pubmed/37693513
http://dx.doi.org/10.1101/2023.09.02.556046