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AP profiling resolves co-translational folding pathway and chaperone interactions in vivo

Natural proteins have evolved to fold robustly along specific pathways. Folding begins during synthesis, guided by interactions of the nascent protein with the ribosome and molecular chaperones. However, the timing and progression of co-translational folding remain largely elusive, in part because t...

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Detalles Bibliográficos
Autores principales: Chen, Xiuqi, Kaiser, Christian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491307/
https://www.ncbi.nlm.nih.gov/pubmed/37693575
http://dx.doi.org/10.1101/2023.09.01.555749

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