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Severe preeclampsia is not associated with significant DNA methylation changes but cell proportion changes in the cord blood - caution on the importance of confounding adjustment
Epigenome-wide DNA methylation analysis (EWAS) is an important approach to identify biomarkers for early disease detection and prognosis prediction, yet its results could be confounded by other factors such as cell-type heterogeneity and patient characteristics. In this study, we address the importa...
Autores principales: | Liu, Wenting, Yang, Xiaotong, Mao, Zhixin, Du, Yuheng, Lassiter, Cameron, AlAkwaa, Fadhl M., Benny, Paula A, Garmire, Lana X |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491383/ https://www.ncbi.nlm.nih.gov/pubmed/37693517 http://dx.doi.org/10.1101/2023.08.31.23294898 |
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