Genetic enhancers of partial PLK1 inhibition reveal hypersensitivity to kinetochore perturbations

Polo-like kinase 1 (PLK1) is a serine/threonine kinase required for mitosis and cytokinesis. As cancer cells are often hypersensitive to partial PLK1 inactivation, chemical inhibitors of PLK1 have been developed and tested in clinical trials. However, these small molecule inhibitors alone are not co...

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Detalles Bibliográficos
Autores principales: Normandin, Karine, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bernard, Alexandre, Bourouh, Mohammed, Bertomeu, Thierry, Tyers, Mike, Archambault, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491399/
https://www.ncbi.nlm.nih.gov/pubmed/37639469
http://dx.doi.org/10.1371/journal.pgen.1010903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491399/
https://www.ncbi.nlm.nih.gov/pubmed/37639469
http://dx.doi.org/10.1371/journal.pgen.1010903

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